Welcome
My research is in the general area of molecular biological
physics. Conformational flexibility and dynamics of protein molecues
is often the key connection between the structure of a protein and its
biological function. My research group is developing analytical and computational
approaches to understand the mechanisms controlling large-scale
(main-chain) structural changes in proteins. Examples include protein
folding, allostery, and conformational changes induced from
interactions with molecular surfaces.
This research employs a variety of theoretical concepts from
statistical mechanics of phase transitions, soft
condensed matter physics, and physical chemistry. It
aims to bridge the gap between analytical theory,
simulation, and experimental measurements to
understand structure, dynamics and function of
biomolecules. For students, this effort provides truly
interdisciplinary research experience at the interface
between physics, chemistry, and biology.