Mechanical quantification of molecular interactions reveals spatiotemporal fluctuations on cell surface

Shakya S, Zhang Z, Ciolli P, Sharma A, Sharma G, Karna D, Pokhrel P, Ji J, Kurokawa M, Zheng Y, Mao H*.

Journal of the American Chemical Society (Accepted)

DOI:

Targeting soluble misfolded oligomers in anti-amyloid research

Vosbein P, Mao H*, and Luo C*.

Nature Reviews Chemistry (2026)

DOI: 10.1038/s41570-026-00867-y

Mechanozyme: an artificial enzyme with a mechanophore framework

Ji J, Pokhrel P, Shakya S, Pokhrel B, Sharma G, Chaudhary P, Shen H, and Mao H*.

Advanced Science (2026) : e75254.

DOI: 10.1002/advs.75254

Kinetically Trapped Ligand Binding in DNA Tandem Repeats

Tahir R, Pandey S, Haller J, Colecchia E, Yangyuoru P, Mao H*.

Biochemistry 65.7 (2026) : 1025-1032.

DOI: 10.1021/acs.biochem.5c00640

This research has been featured in the cover page of the Biochemistry, Volume 65, issue 7, April 7, 2026.

High-Throughput Characterization of Individual Microdroplets Unveils Ultrasound-enhanced Radical Production

Haun J, Ji J, Mao H*.

Journal of the American Chemical Society (2026)

DOI:10.1021/jacs.5c20375

Highlighted in X-MOL News: Click Here

Modulating a massive set of biomolecular structures by sono-mechanical force

Pokhrel P, Sharma G, Jenyk J, Lower A, Ji J, Shakya S, Haun J, Mao H*.

Advanced Science (2025): e11687.

DOI: 10.1002/advs.202511687

Nucleation Dynamics in the Beta Amyloid Dimerization Revealed by Single Molecule Fingerprinting

Kafi A.K.M, Danielsen M.B, Song S, Karna D, Shakya S, Ji J, Hao Y, Penanes P.A, Kjeldsen F, Mao H*, Lou C*.

Cell Reports Physical Science (2025)

DOI: 10.1016/j.xcrp.2025.102930

Degradation of G-Quadruplex-Binding Proteins by G4L-PROTAC via Quaternary Complex Formation

Nohara R, Tanaya Y, Sheikhi M.J, Chaudhary P, Sharma G, Mao H, Nagasawa K, Tera M*.

Angewandte Chemie International Edition (2025): e202515045

DOI: 10.1002/anie.202515045

NIR-Activatable, Sequence-Specific Metal-Nucleic Acid Scaffolds for Responsive Uncaging

Sharma A, Kshetri M, Karna D, Amin A. M, Akter S, Mao H*, Zheng Y*.

Angewandte Chemie International Edition (2025): e202514717

DOI: 10.1002/anie.202514717

Chiral Matching between Nucleic Acids and Polypeptides Facilitates Liquid-liquid Phase Separation (LLPS)

Pokhrel P, Zhang Z, Ji J, Shakya S, Jenyk J, Lower A, Janssen M, Mao H*.

The Journal of Physical Chemistry Letters 16.36 (2025): 9545-9552

DOI: 10.1021/acs.jpclett.5c02218

Fluorogenic Linkage Integration for Nonfluorescent Transformations (FLINT)

Pokhrel B, Farhana F, Zuo L, Stratton RL, Pokhrel P, Hossain MA, Ji J, Mao H, Shen H*.

Chemical & Biomedical Imaging 3.4 (2025): 253-259.

DOI: 10.1021/cbmi.4c00114

Decoupling Activity and Specificity in Coronazymes

Ji J, Zuo L, Pokhrel B, Pokhrel P, Shakya S, Shen H*, Mao H*.

Small 21.14 (2025): 2500783.

DOI: 10.1002/smll.202500783

Logic-Gated Modulation of Cell Migration via Mesoscale Mechanical Uncaging Effects

Karna D, Watanabe S, Sharma G, Sharma A, Zheng Y, Kawamata I, Suzuki Y*, Mao H*.

ACS Nano 19.8 (2025): 8058-8069.

DOI: 10.1021/acsnano.4c16194

De novo design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers

Pandey S, Danielsen MB, Xiang Y, Zhang Z, Sharma G, Jeon BT, Song S, Hao Y, Zhang G, Christensen NJ, Sorensen KK, Harris P, Pokhrel P, Cunningham R, Kim MH, Leng Y, Lou C*, Mao H*.

Cell Reports Physical Science 5.12 (2024).

DOI: 10.1016/j.xcrp.2024.102336

Electroanalytical Quantification of DNA Chirality

Kafi AKM, Pokhrel P, Shen H*, Mao H*.

Langmuir 40.47 (2024): 24968-24977.

DOI: 10.1021/acs.langmuir.4c03055

Modulation of dynamic DNA G-quadruplex structures in the hTERT promoter region by ligands

Karna D, Liang L, Sharma G, Mandal S, Asamitsu S, Kawamoto Y, Hashiya K, Bando T, Sugiyama H, Mao H*.

Nucleic Acids Research 52.18 (2024): 10775-10787.

DOI: 10.1093/nar/gkae754

Catalytic Relaxation of Kinetically Trapped Intermediates by DNA Chaperones

Pokhrel P, Karna D, Jonchhe S, Mao H*.

Journal of the American Chemical Society 146.19 (2024): 13046-13054.

DOI: 10.1021/jacs.3c14350

Dynamic Structures and Fast Transition Kinetics of Oxidized G-Quadruplexes

Ji J, Sharma A, Pokhrel P, Karna D, Pandey S, Zheng YR*, Mao H*.

Small 20.35 (2024): 2400485.

DOI: 10.1002/smll.202400485

Quality Research Follows the Power Law

Mao H*, Chen J*.

Journal of Scientometric Research 12.3 (2023): 570-576.

DOI: 10.5530/jscires.12.3.054

Peptide-DNA conjugates as building blocks for de novo design of hybrid nanostructures

Danielsen MB, Mao H, Lou C*.

Cell Reports Physical Science 4.10 (2023).

DOI: 10.1016/j.xcrp.2023.101620

Chemo-mechanical forces modulate the topology dynamics of mesoscale DNA assemblies

Karna D, Mano E, Ji J, Kawamata I*, Suzuki Y*, Mao H*.

Nature Communications 14.1 (2023): 6459.

DOI: 10.1038/s41467-023-41604-z

'Behind the paper'

This article was also featured in Nature Communications Editor's highlight.

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

Huang Y*, Wen J, Ramirez LM, Gumusdil E, Pokhrel P, Man VH, Ye H, Han Y, Liu Y, Li P, Su Z, Wang J, Mao H, Zweckstetter M, Perrett S, Wu S*, Gao M*.

Nature Communications 14.1 (2023): 5444.

10.1038/s41467-023-41241-6

Single-Molecular Dissection of Liquid-Liquid Phase Transitions

Pokhrel P, Jonchhe S, Pan W, Mao H*.

Journal of the American Chemical Society 145.31 (2023): 17143-17150.

DOI: 10.1021/jacs.3c03812

Amalgamation of DNAzymes and Nanozymes in a Coronazyme

Zuo L, Ren K, Guo X, Pokhrel P, Pokhrel B, Hossain MA, Chen ZX, Mao H*, Shen H*.

Journal of the American Chemical Society 145.10 (2023): 5750-5758.

DOI: 10.1021/jacs.2c12367

This research has been featured in the cover page of the Journal of the American Chemical Society, Volume 145, March 15, 2023.

Ensemble Force Spectroscopy of a G-Quadruplex Cluster on a Single-Molecule Platform

Pokhrel P, Wang J, Selvam S, Jonchhe S, Mandal S, Mao H.

Biomacromolecules 23.11 (2022): 4795-4803.

DOI: 10.1021/acs.biomac.2c00959

Mechanical Stability of DNA Corona Phase on Gold Nanospheres

Pokhrel P, Ren K, Shen H, Mao H.

Langmuir 38.44 (2022): 13569-13576.

DOI: 10.1021/acs.langmuir.2c02251

Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes

Pandey S, Jonchhe S, Mishra S, Emura T, Sugiyama H, Endo M, Mao H.

The journal of physical chemistry letters 13.37 (2022): 8692-8698.

DOI: 10.1021/acs.jpclett.2c02253

Ensemble Force Spectroscopy by Shear Forces

Pokhrel P, Hu C, Mao H.

Journal of visualized experiments: JoVE 185 (2022): 10-3791.

DOI: 10.3791/63741

Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes

Chowdhury S, Wang J, Nuccio SP, Mao H, Di Antonio M.

Nucleic Acids Research 50.13 (2022): 7247-7259.

DOI: 10.1093/nar/gkac569

Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex

Pokhrel P, Sasaki S, Hu C, Karna D, Pandey S, Ma Y, Nagasawa K, Mao H.

Analytical Biochemistry 649 (2022): 114693.

DOI: 10.1016/j.ab.2022.114693

Single-Molecule Mechanochemical Sensing

Hu C, Tahir R, Mao H.

Accounts of chemical research 55.9 (2022): 1214-1225.

DOI: 10.1021/acs.accounts.1c00770

Small Molecules Modulate Liquid-to-Solid Transitions in Phase-Separated Tau Condensates

Jonchhe S, Pan W, Pokhrel P, Mao H.

Angewandte Chemie International Edition 61.23 (2022): e202113156.

DOI: 10.1002/anie.202113156

Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity

Jonchhe S, Pandey S, Beneze C, Emura T, Sugiyama H, Endo M, Mao H.

Nucleic acids research 50.2 (2022): 697-703.

DOI: 10.1093/nar/gkab1298

Chirality transmission in macromolecular domains

Pandey S, Mandal S, Danielsen MB, Brown A, Hu C, Christensen NJ, Kulakova AV, Song S, Brown T, Jensen KJ, Wengel J, Lou C, Mao H.

Nature Communications 13.1 (2022): 76.

DOI: 10.1038/s41467-021-27708-4

This research has been reported in EurekAlert! news release 10-Jan-2022. Will this new superpower molecule revolutionize science?

Also highlighted in X-MOLNews. (click here)

And in ebiotrade.com (click here)

Direct Measurement of Intermolecular Mechanical Force for Nonspecific Interactions between Small Molecules

Pandey S, Xiang Y, Friedrich D, Leng Y, Mao H.

The journal of physical chemistry letters 12.46 (2021): 11316-11322.

DOI: 10.1021/acs.jpclett.1c03142

Measurement of Single-Molecule Forces in Cholesterol and Cyclodextrin Host-Guest Complexes

Pandey S, Xiang Y, Walpita Kankanamalage DV, Jayawickramarajah J, Leng Y, Mao H.

The Journal of Physical Chemistry B 125(40), 11112-11121.

DOI: 10.1021/acs.jpcb.1c03916

DNA origami nano-mechanics

Ji J, Karna D, Mao H.

Chemical Society Reviews 50.21 (2021): 11966-11978.

DOI: 10.1039/D1CS00250C

Mechanical unfolding of ensemble biomolecular structures by shear force

Hu C, Jonchhe S, Pokhrel P, Karna D, Mao H.

Chemical Science 12.30 (2021): 10159-10164.

DOI: 10.1039/D1SC02257A

This research has been featured in the cover page of the journal Chemical Science.

Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings

Karna D, Stilgenbauer M, Jonchhe S, Ankai K, Kawamata I, Cui Y, Zheng Y-R, Suzuki Y, Mao H.

Bioconjugate Chemistry 32.2 (2021): 311-317.

DOI: 10.1021/acs.bioconjchem.0c00674

Mechanochemical properties of DNA origami nanosprings revealed by force jumps in optical tweezers

Karna D, Pan W, Pandey S, Suzuki Y, Mao H.

Nanoscale 13 (2021): 8425-8430.

DOI: 10.1039/D0NR08605C

Cooperative hetero-ligands interaction with G-quadruplexes shows evidence of allosteric binding

Pandey S, Li Y, Young M, Mandal S, Lu L, Shelley J, Mao H

Biochemistry 59.37 (2020): 3438-3446

DOI: 10.1021/acs.biochem.0c00351

Ensemble sensing using single-molecule DNA copolymers

Jonchhe S, Selvam S, Karna D, Mandal S, Wales-McGrath B, Mao H

Analytical Chemistry 92.19 (2020): 13126-13133

DOI: 10.1021/acs.analchem.0c02196

A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials

Li Q, Zhao J, Liu L, Jonchhe S, Rizzuto F, Mandal S, He H, Wei S, Sleiman H, Mao H, Mao C

Nature Materials 19 (2020): 1012-1018

• Highlighted in C&EN: Melamine mediates formation of polythymine duplexes
• Recommended at F1000 by Prof. Francesco Ricci: A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials
• Featured in Cailiaoniu.com: Purdue & Kent State & McGill Nat. Mater.: A new breakthrough in the artificial construction of double-stranded DNA!
• Featured in Nanoer.com: Nature Materials: ?????-???????????DNA???? (Chinese)

Duplex DNA is Weakened in Nanoconfinement

Jonchhe S, Pandey S, Karna D, Pokhrel P, Mishra S, Sugiyama H, Endo M, Mao H

Journal of the American Chemical Society 142.22 (2020): 10042-10049

DOI: 10.1021/jacs.0c01978

Detecting the Coronavirus (COVID-19)

Pokhrel P, Hu C, Mao H

ACS Sensors 5.8 (2020): 2283-2296

DOI: 10.1021/acssensors.0c01153

Chiral Interaction Is a Decisive Factor To Replace D-DNA with L-DNA Aptamers

Feng X, Cui Y, Zhang J, Tang A, Mao H, Kong D

Analytical Chemistry 92.9 (2020): 6470-6477

DOI: 10.1021/acs.analchem.9b05676

Chaperone Assisted Host-Guest Interactions Revealed by Single-Molecule Force Spectroscopy

Pandey S, Kankanamalage D, Zhou X, Hu C, Isaacs L, Jayawickramarajah J, Mao H

Journal of the American Chemical Society 141.46 (2019): 18385-18389

DOI: 10.1021/jacs.9b09019

Single-Molecule Topochemical Analyses for Large-Scale Multiplexing Tasks

Mandal S, Zhang X, Pandey S, Mao H

Analytical Chemistry 91.21 (2019): 13485-13493

DOI: 10.1021/acs.analchem.9b02483

Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface

Mandal S, Kawamoto Y, Yue Z, Hashiya K, Cui Y, Bando T, Pandey S, Hoque M, Hossain M, Sugiyama H, Mao H

Nucleic Acids Research 47.7 (2019): 3295-3305

DOI: 10.1093/nar/gkz135

Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex

Jonchhe S, Ghimire C, Cui Y, Sasaki S, McCool M, Park S, Iida K, Nagasawa K, Sugiyama H, Mao H

Angewandte Chemie International Edition 58 (2019): 877-881

DOI: 10.1002/anie.201811046

Single-Molecule Investigations of G-Quadruplex

Mandal S, Hoque M, Mao H

G-Quadruplex Nucleic Acids, Springer, 2019 [Book Chapter]

Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures

Jonchhe S, Mao H

Biomimetic Sensing, Springer, 2019 [Book Chapter]

Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts

Punnoose J, Ma Y, Hoque ME, Cui Y, Sasaki S, Guo AH, Nagasawa K, Mao H

Biochemistry 57.51 (2018): 6946-6955

DOI: 10.1021/acs.biochem.8b00957

Mechanical Cooperativity in DNA Cruciform Structures

Mandal S, Selvam S, Cui Y, Hoque ME, Mao H

ChemPhysChem 19 (2018): 2627-2634

DOI: 10.1002/cphc.201800580

This research has been featured in the cover page of the journal ChemPhysChem.

Decreased water activity in nanoconfinement contributes to the folding of G-quadruplex and i-motif structures

Jonchhe S, Pandey S, Emura T, Hidaka K, Hossain MA, Shrestha P, Sugiyama H, Endo M, Mao H

PNAS 115.38 (2018): 9539-9544

DOI: 10.1073/pnas.1805093115

Single-Molecule Mechanochemical pH Sensing Revealing the Proximity Effect of Hydroniums Generated by an Alkaline Phosphatase

Shrestha P, Cui Y, Wei J, Jonchhe S, Mao H

Analytical Chemistry 90.3 (2018): 1718-1724

DOI: 10.1021/acs.analchem.7b04548

A New Concentration Jump Strategy Reveals the Lifetime of i-Motif at Physiological pH without Force

Jonchhe S, Shrestha P, Ascencio K, Mao H

Analytical Chemistry 90.5 (2018): 3205-3210

DOI: 10.1021/acs.analchem.7b04661

Quantification of Chemical and Mechanical Effects on the Formation of the G-Quadruplex and i-Motif in Duplex DNA

Selvam S, Mandal S, Mao H

Biochemistry 56.35 (2017): 4616-4625

DOI: 10.1021/acs.biochem.7b00279

This research has been featured in the cover page of the journal Biochemistry.

Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units

Punnoose J, Ma Y, Li Y, Sakuma M, Mandal S, Nagasawa K, Mao H

Journal of the American Chemical Society 139.22 (2017): 7476-7484

DOI: 10.1021/jacs.7b00607

Confined space facilitates G-quadruplex formation

Shrestha P, Jonchhe S, Emura T, Hidaka K, Endo M, Sugiyama H, Mao H

Nature Nanotechnology 12 (2017): 582-588

DOI: 10.1038/nnano.2017.29

This research has been highlighted in Science Daily and Eurekalert.

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

Sutherl C, Cui Y, Mao H, Hurley L

Journal of the American Chemical Society 138.42 (2016): 14138-14151

DOI: 10.1021/jacs.6b09196

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

Kang H, Cui Y, Yin H, Scheid A, Hendricks W, Schmidt J, Sekulic A, Kong D, Trent J, Gokhale V, Mao H, Hurley L

Journal of the American Chemical Society 138.41 (2016): 13673-13692

DOI: 10.1021/jacs.6b07598

Mechanochemical Sensing of Single and Few Hg(II) Ions Using Polyvalent Principles

Mandal S, Selvam S, Shrestha P, Mao H

Analytical Chemistry 88.19 (2016): 9479-9485

DOI: 10.1021/acs.analchem.6b01899

Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores

Shrestha P, Emura T, Koirala D, Cui Y, Hidaka K, Maximuck W, Endo M, Sugiyama H, Mao H

Nucleic Acids Research 44.14 (2016): 6574-6582

DOI: 10.1093/nar/gkw431

Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA

Cui Y, Kong D, Ghimire C, Xu C, Mao H

Biochemistry 55.15 (2016): 2291-2299

DOI: 10.1021/acs.biochem.6b00016

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding

Selvam S, Yu Z, Mao H

Nucleic Acids Research 44.1 (2016): 45-55

DOI: 10.1093/nar/gkv1187

A Molecular Tuning Fork in Single-Molecule Mechanochemical Sensing

Mandal S, Koirala D, Selvam S, Ghimire C, Mao H

Angewandte Chemie International Edition 127 (2015): 7717-7721

DOI: 10.1002/ange.201502580

Mechanochemical Sensing: A Biomimetic Sensing Strategy

Shrestha P, Mandal S, Mao H

ChemPhysChem 16 (2015): 1829-1837

DOI: 10.1002/cphc.201500080

Dissecting Cooperative Communications in a Protein with a High-Throughput Single-Molecule Scalpel

Yu Z, Cui Y, Selvam S, Ghimire C, Mao H

ChemPhysChem 16 (2015): 223-232

DOI: 10.1002/cphc.201402443

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex

Yangyuoru P, DiAntonio M, Ghimire C, Biffi G, Balasubramanian S, Mao H

Angewandte Chemie International Edition 54 (2015): 910-913

DOI: 10.1002/anie.201408113

Mechanochemical Sensing

Shrestha P, Mandal S, Mao H

RNA and DNA Diagnostics, Springer (2015) [Book Chapter]

DOI: 10.1007/978-3-319-17305-4_12

Interaction of G-quadruplexes in the Full-length 3' Human Telomeric Overhang

Punnoose J, Cui Y, Koirala D, Yangyuoru P, Ghimire C, Shrestha P, Mao H

Journal of the American Chemical Society 136.52 (2014): 18062-18069

DOI: 10.1021/ja510079u

Direct Quantification of Loop Interaction and p-p Stacking for G-Quadruplex Stability at the Submolecular Level

Ghimire C, Park S, Iida K, Yangyuoru P, Otomo H, Yu Z, Nagasawa K, Sugiyama H, Mao H

Journal of the American Chemical Society 136.44 (2014): 15537-15544

DOI: 10.1021/ja503585h

Quantification of Topological Coupling between DNA Superhelicity and G-quadruplex Formation

Selvam S, Koirala D, Yu Z, Mao H

Journal of the American Chemical Society 136.40 (2014): 13967-13970

DOI: 10.1021/ja5064394

Intermediates Stabilized by Tryptophan Pairs Exist in Trpzip Beta-Hairpins

Yu Z, Selvam S, Mao H

Biochemistry 53.38 (2014): 5978-5986

DOI: 10.1021/bi500194g

Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures

Koirala D, Shrestha P, Emura T, Hidaka K, Mandal S, Endo M, Sugiyama H, Mao H

Angewandte Chemie International Edition 126 (2014): 8275-8279

DOI: 10.1002/ange.201404043

This research has been featured in the cover page of the journal.

Nascent RNA transcripts facilitate the formation of G-quadruplexes

Shrestha P, Xiao S, Dhakal S, Tan Z, Mao H

Nucleic Acids Research 42.11 (2014): 7236-7246

DOI: 10.1093/nar/gku331

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL

Cui Y, Koirala D, Kang H, Dhakal S, Yangyuoru P, Hurley L, Mao H

Nucleic Acids Research 42.9 (2014): 5755-5764

DOI: 10.1093/nar/gku170

This research has been highlighted in Chemistry and Engineering News (C&EN), 2014 as Role Of Mysterious Folded DNA Structures Revealed At Last.

Yoctoliter Thermometry for Single-Molecule Investigations: A Generic Bead-on-a-Tip Temperature-Control Module

Koirala D, Punnoose J, Shrestha P, Mao H

Angewandte Chemie International Edition 53 (2014): 3470-3474

DOI: 10.1002/anie.201310172

This research has been highlighted in Nature Nanotechnology as A controlled jump.

This research has been featured in the cover page of the journal.

Controlled Particle Collision Leads to Direct Observation of Docking and Fusion of Lipid Droplets in an Optical Trap

Ghimire C, Koirala D, Mathis M, Kooijman E, Mao H

Langmuir 30.5 (2014): 1370-1375

DOI: 10.1021/la404497v

Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

Yangyuoru P, Zhang A, Shi Z, Koirala D, Balasubramanian S, Mao H

ChemBioChem 14.15 (2013): 1931-1935

DOI: 10.1002/cbic.201300350

Mechanical affinity as a new metrics to evaluate binding events

Koirala D, Yangyuoru P, Mao H

Reviews in Analytical Chemistry 32.3 (2013): 197-208

DOI: 10.1515/revac-2013-0004

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions

Dhakal S, Cui Y, Koirala D, Ghimire C, Kushwaha S, Yu Z, Yangyuoru P, Mao H

Nucleic Acids Research 41.6 (2013): 3915-3923

DOI: 10.1093/nar/gkt038

Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences

Koirala D, Ghimire C, Bohrer C, Sannohe Y, Sugiyama H, Mao H

Journal of the American Chemical Society 135.6 (2013): 2235-2241

DOI: 10.1021/ja309668t

Non-B DNA Structures Show Diverse Conformations and Complex Transition Kinetics Comparable to RNA or Proteins-A Perspective from Mechanical Unfolding and Refolding Experiments

Yu Z, Mao H

The Chemical Record 13 (2013): 102-116

DOI: 10.1002/tcr.201200021

G-quadruplex Nanostructures Probed at the Single Molecular Level by Force-based Methods

Dhakal S, Mao H, Rajendran A, Endo M, Sugiyama H

Guanine Quartets: Structure and Application (2012): Book Chapter

DOI: 10.1039/9781849736954-00073

Click Chemistry Assisted Single-Molecule Fingerprinting Reveals a 3D Biomolecular Folding Funnel

Yu Z, Koirala D, Cui Y, Easterling L, Zhao Y, Mao H

Journal of the American Chemical Society 134.30 (2012): 12338-12341

DOI: 10.1021/ja303218s

Intramolecular Folding in Human ILPR Fragment with Three C-Rich Repeats

Dhakal S, Lafontaine J, Yu Z, Koirala D, Mao H

PLOS ONE 7.6 (2012): e39271

DOI: 10.1371/journal.pone.0039271

G-Quadruplex and i-Motif Are Mutually Exclusive in ILPR Double-Stranded DNA

Dhakal S, Yu Z, Konik R, Cui Y, Koirala D, Mao H

Biophysical Journal 102 (2012): 2575-2584

DOI: 10.1016/j.bpj.2012.04.024

Single-Molecule Measurements of the Binding between Small Molecules and DNA Aptamers

Yangyuoru P, Dhakal S, Yu Z, Koirala D, Mwongela S, Mao H

Analytical Chemistry 84.12 (2012): 5298-5303

DOI: 10.1021/ac300427d

Tertiary DNA Structure in the Single-Stranded hTERT Promoter Fragment Unfolds and Refolds by Parallel Pathways via Cooperative or Sequential Events

Yu Z, Gaerig V, Cui Y, Kang H, Gokhale V, Zhao Y, Hurley L, Mao H

Journal of the American Chemical Society 134.11 (2012): 5157-5164

DOI: 10.1021/ja210399h

Intramolecular folding in three tandem guanine repeats of human telomeric DNA

Koirala D, Mashimo T, Sannohe Y, Yu Z, Mao H, Sugiyama H

Chemical Communications 48 (2012): 2006-2008

DOI: 10.1039/C2CC16752B

Detection of Single Nucleotide Polymorphism Using Tension-Dependent Stochastic Behavior of a Single-Molecule Template

Koirala D, Yu Z, Dhakal S, Mao H

Journal of the American Chemical Society 133.26 (2011): 9988-9991

DOI: 10.1021/ja201976r

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

Koirala D, Dhakal S, Ashbridge B, Sannohe Y, Rodriguez R, Sugiyama H, Balasubramanian S, Mao H

Nature Chemistry 3 (2011): 782-787

DOI: 10.1038/nchem.1126

Highlighted in News and Views in Nature Chemistry: Untying a nanoscale knot

Coexistence of an ILPR i-Motif and a Partially Folded Structure with Comparable Mechanical Stability Revealed at the Single-Molecule Level

Dhakal S, Schonhoft J, Koirala D, Yu Z, Basu S, Mao H

Journal of the American Chemical Society 132.26 (2010): 8991-8997

DOI: 10.1021/ja100944j

ILPR repeats adopt diverse G-Quadruplex conformations that determine insulin binding

Schonhoft J, Das A, Achamyeleh F, Samdani S, Sewell A, Mao H, Basu S

Biopolymers 93.1 (2010): 21-31

DOI: 10.1002/bip.21289

ILPR G-Quadruplexes Formed in Seconds Demonstrate High Mechanical Stabilities

Yu Z, Schonhoft J, Dhakal S, Bajracharya R, Hegde R, Basu S, Mao H

Journal of the American Chemical Society 131.5 (2009): 1876-1882

DOI: 10.1021/ja806782s

This research has also been recommended by Professor Stephen Neidle at F1000 faculty website as ILPR G-quadruplexes formed in seconds demonstrate high mechanical stabilities.

Direct experimental evidence for quadruplex-quadruplex interaction within the human ILPR

Schonhoft J, Bajracharya R, Dhakal S, Yu Z, Mao H, Basu S

Nucleic Acids Research 37.10 (2009): 3310-3320

DOI: 10.1093/nar/gkp181